{"id":13214,"date":"2025-12-10T13:36:47","date_gmt":"2025-12-10T13:36:47","guid":{"rendered":"https:\/\/www.healthnews.ie\/?p=13214"},"modified":"2026-01-27T15:40:03","modified_gmt":"2026-01-27T15:40:03","slug":"irish-neurosurgery-and-neurology-teams-leading-global-trials-and-advancing-patient-care","status":"publish","type":"post","link":"https:\/\/www.healthnews.ie\/healthcare-innovations\/irish-neurosurgery-and-neurology-teams-leading-global-trials-and-advancing-patient-care\/","title":{"rendered":"Irish neurosurgery and neurology teams leading global trials and advancing patient care"},"content":{"rendered":"\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" class=\"ab-profile-avatar wp-image-13215\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/10132830\/vicky-1765373309-Lisa-Headshot.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/10132830\/vicky-1765373309-Lisa-Headshot.jpg 600w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/10132830\/vicky-1765373309-Lisa-Headshot-125x125.jpg 125w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Lisa Costelloe<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Consultant Neurologist at Beaumont Hospital<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" class=\"ab-profile-avatar wp-image-13264\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/27153921\/vicky-1769528360-Untitled-design-6.png\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/27153921\/vicky-1769528360-Untitled-design-6.png 400w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/27153921\/vicky-1769528360-Untitled-design-6-125x125.png 125w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Mohsen Javadpour<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Consultant Neurosurgeon at Beaumont Hospital<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<p><em>Professor Mohsen Javadpour and Dr Lisa Costelloe discuss how breakthrough studies in brain aneurysms and Multiple Sclerosis (MS) monitoring are helping clinicians deliver safer, smarter and more effective neurosurgical and neurological care.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Consultant neurosurgeon Professor Mohsen Javadpour speaks of his special interest in brain aneurysm research, highlighting its tangible impact on risk factor consultation and interventional treatment pathways.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-brain-aneurysm-research\"><strong>Brain aneurysm research <\/strong><strong><\/strong><\/h2>\n\n\n\n<p>\u201cAbout 3% of the population harbour an aneurysm, most of which never rupture. So, what makes an aneurysm rupture?\u201d he asks.<\/p>\n\n\n\n<p>To answer this, Javadpour and his team built a prospective risk model database at Beaumont Hospital, alongside local audit nurses and nurse specialists who\u2019ve helped to collect data on over 1,000 cases of subarachnoid haemorrhage (SAH).<\/p>\n\n\n\n<p>\u201cAnalysing cases of ruptured aneurysm helped us to clearly identify major risk factors: hypertension increases risk 2.5-fold, smoking eightfold, but combined, the risk rises thirtyfold. This changes the way we speak to our patients about prevention.\u201d<\/p>\n\n\n\n<p>Further research includes leading an international multicentre study examining risk factors for aneurysm recurrence following treatment and the prospective use of aggressive, early intervention for poor-grade SAH. \u201cPoor grade SAH has traditionally been managed in a delayed fashion, but our study of 250 patients showed that early treatment allowed over half of patients to survive and remain independent, particularly younger patients.\u201d<\/p>\n\n\n\n<p>\u201cNeurosurgical research involves assessing high-risk procedures, making trial design and patient recruitment challenging,\u201d continues Javadpour. \u201cDespite this, neurosurgery has been at the forefront of randomised controlled trials, with our clinical research centre running and participating in multiple international studies.\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>This is an extremely exciting and fruitful area of research at the moment, with a real potential to drive meaningful change for MS management<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-novel-outcome-measure-for-multiple-sclerosis\"><strong>Novel outcome measure for multiple sclerosis<\/strong><strong><\/strong><\/h2>\n\n\n\n<p>The last decade has transformed multiple sclerosis (MS) care, with an expansion of disease-modifying therapies providing hope to the 2.9 million people affected globally. To measure the effectiveness of potential drug candidates, novel outcome measures are urgently needed to capture subtle changes in disease activity and progression. Dr Lisa Costelloe, consultant neurologist, explains.<\/p>\n\n\n\n<p>\u201cOutcome measures for MS need to reflect the full diversity of the symptoms experienced,\u201d she explains. \u201cWe often see patients with MS who feel their condition has worsened, but their MRI hasn\u2019t changed. In addition, cognitive difficulties, fatigue, visual changes and subtle disease progression cannot always be captured with standard MRI monitoring.\u201d<\/p>\n\n\n\n<p>Driving effective patient management, Dr Costelloe\u2019s team is investigating a novel potential biomarker, ocular microtremor (OMT), alongside measures of gait and cognition, as well as standard clinical monitoring. With funding from Enterprise Ireland and collaboration with local medtech company, <a href=\"https:\/\/headdiagnostics.com\/\">Head Diagnostics<\/a>, the research hopes to provide more comprehensive, accurate and real-time data on MS disease activity.<\/p>\n\n\n\n<p>\u201cWe\u2019re lucky to receive funding for this project, without which, it wouldn\u2019t be possible,\u201d continues Costelloe. \u201cThis is an extremely exciting and fruitful area of research at the moment, with a real potential to drive meaningful change for MS management.\u201d<\/p>\n\n\n\n<p>The RCSI CRC supports research within Beaumont Hospital, providing the infrastructure, support and high-level quality management needed to run complex clinical trials in-house, allowing principal investigators at Beaumont Hospital to \u201cengage ethically and effectively in research,\u201d explains Javadpour. \u201cWe have a strong track record of research at Beaumont, and we\u2019re well equipped for clinical trials.\u201d<\/p>\n\n\n\n<p>\u201cThe clinical research centre provides the perfect infrastructure to conduct high-quality clinical research,\u201d explains Dr Costelloe. \u201cWe have the expertise, allied services on site and a large population of neurological patients, making it an excellent platform for securing research funding.\u201d<\/p>\n\n\n\n<p>The expertise and infrastructure of both Beaumont Hospital and the RCSI CRC combined make it the perfect partner for international clinical research. This is evidenced by involvement in the recent neurosurgical study \u2014 the BONANZA trial \u2014 within which Beaumont Hospital is the highest recruitment site in Europe.<\/p>\n\n\n<!DOCTYPE html PUBLIC \"-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\" \"http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\">\n<html><body><div style=\"text-align:center\" class=\"wp-block-atomic-blocks-ab-button ab-block-button\"><a href=\"https:\/\/www.rcsi.com\/dublin\/research-and-innovation\/research\/resources-and-facilities\/clinical-research-centre\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"ab-button ab-button-shape-rounded ab-button-size-medium fb-pixel\" style=\"color:#ffffff;background-color:#000000\">Click here to learn more<\/a><\/div>\n<\/body><\/html>\n","protected":false},"excerpt":{"rendered":"<p>Professor Mohsen Javadpour and Dr Lisa Costelloe discuss how breakthrough studies in brain aneurysms and Multiple Sclerosis (MS) monitoring are helping clinicians deliver safer, smarter and more effective neurosurgical and neurological care. Consultant neurosurgeon Professor Mohsen Javadpour speaks of his special interest in brain aneurysm research, highlighting its tangible impact on risk factor consultation and &hellip; <a href=\"https:\/\/www.healthnews.ie\/healthcare-innovations\/irish-neurosurgery-and-neurology-teams-leading-global-trials-and-advancing-patient-care\/\">Continued<\/a><\/p>\n","protected":false},"author":163,"featured_media":13217,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5973],"tags":[5995],"class_list":["post-13214","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthcare-innovations","tag-healthcare-innovations"],"acf":[],"featured_image_src":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/10133605\/vicky-1765373764-GettyImages-2191191744-600x400.jpg","featured_image_src_square":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/12\/10133605\/vicky-1765373764-GettyImages-2191191744-600x600.jpg","author_info":{"display_name":"Mica Robertson","author_link":"https:\/\/www.healthnews.ie\/author\/micarobertson\/"},"vicky_category_order":[{"category_id":5973,"order":"2"}],"vicky_index_order":"","_links":{"self":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/13214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/users\/163"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/comments?post=13214"}],"version-history":[{"count":3,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/13214\/revisions"}],"predecessor-version":[{"id":13265,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/13214\/revisions\/13265"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media\/13217"}],"wp:attachment":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media?parent=13214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/categories?post=13214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/tags?post=13214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}