{"id":12345,"date":"2025-03-20T12:51:18","date_gmt":"2025-03-20T12:51:18","guid":{"rendered":"https:\/\/www.healthnews.ie\/?p=12345"},"modified":"2025-03-24T09:16:05","modified_gmt":"2025-03-24T09:16:05","slug":"new-emergency-trial-status-accelerates-major-trauma-research","status":"publish","type":"post","link":"https:\/\/www.healthnews.ie\/clinical-trials\/new-emergency-trial-status-accelerates-major-trauma-research\/","title":{"rendered":"New emergency trial status accelerates major trauma research"},"content":{"rendered":"\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"562\" height=\"563\" class=\"ab-profile-avatar wp-image-12346\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124319\/vicky-1742474599-Screenshot-2025-03-20-at-12.42.40.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124319\/vicky-1742474599-Screenshot-2025-03-20-at-12.42.40.jpg 562w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124319\/vicky-1742474599-Screenshot-2025-03-20-at-12.42.40-125x125.jpg 125w\" sizes=\"auto, (max-width: 562px) 100vw, 562px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Prof Alistair Nichol<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Director of the Irish Critical Care-Clinical Trials Network, University College Dublin and Consultant Intensivist, St Vincent\u2019s University Hospital<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"397\" class=\"ab-profile-avatar wp-image-12347\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124457\/vicky-1742474697-Screenshot-2025-03-20-at-12.44.23.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124457\/vicky-1742474697-Screenshot-2025-03-20-at-12.44.23.jpg 400w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124457\/vicky-1742474697-Screenshot-2025-03-20-at-12.44.23-125x125.jpg 125w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Dr Kate Ainscough<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Irish Critical Care-Clinical Trials Network Manager<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" class=\"ab-profile-avatar wp-image-12348\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124554\/vicky-1742474753-Catherine-G_photo_Feb-2025.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124554\/vicky-1742474753-Catherine-G_photo_Feb-2025.jpg 400w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124554\/vicky-1742474753-Catherine-G_photo_Feb-2025-125x125.jpg 125w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Catherine Guinane<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Irish Critical Care Patient and Public Involvement Group (ICC-PPI) Representative<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<p><em>Major trauma is a leading cause of critical illness, often requiring intensive care, organ support and mechanical breathing support, with young adults disproportionately affected.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>There is a growing need for effective pharmacological and non-pharmacological therapies which can reduce injury impact and improve recovery and patient outcomes following major trauma. Prof Alistair Nichol, Director of the <a href=\"https:\/\/iccctn.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Irish Critical Care-Clinical Trials Network<\/a> (ICC-CTN), explains: \u201cTrauma is a major cause of death, often affecting younger patients. Advancements in trauma care will provide huge benefits for families across Ireland.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-improving-treatments-for-critically-ill-patients\"><strong>Improving treatments for critically ill patients<\/strong><\/h2>\n\n\n\n<p>The ICC-CTN delivers a national portfolio of <a href=\"https:\/\/iccctn.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">critical care trials<\/a> seeking to identify treatments that can improve outcomes for critically ill patients, including trauma patients.<\/p>\n\n\n\n<p>\u201cA key focus of our research is on biological sampling. By examining markers in critically ill patients\u2019 blood, we can predict injury severity and recovery, and identify therapeutic targets,\u201d explains Prof Nichol. \u201cThese efforts, plus recent changes within the clinical trials landscape are some ways in which we are advancing research in this space.\u201d<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>The most important thing is for <br>patients to be given the best available <br>treatment at the appropriate time.<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-new-emergency-trial-status\"><strong>New emergency trial status <\/strong><strong><\/strong><\/h2>\n\n\n\n<p>The new emergency trial status which came into force under the EU Clinical Trials Regulation, means greater access to research than ever before. \u201cPrior to this new regulation, patients who were unconscious were often unable to participate in emergency medication research, but this change opens up new opportunities to advance trauma care for these patients.\u201d Prof Nichol continues: \u201cOur EPO-TRAUMA trial is aiming to enrol 2,500 mechanically ventilated ICU patients following unplanned major trauma and investigate the use of erythropoietin. Where family may not be immediately available to provide agreement to participate, the new regulations allow us to enrol more patients and provide this treatment early, under strict conditions.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-patient-and-public-involvement\"><strong>Patient and public involvement<\/strong><strong><\/strong><\/h2>\n\n\n\n<p>Dr Kate Ainscough, Irish Critical Care-Clinical Trials Network Manager, says: \u201cWe know from patient and public involvement (PPI), our public survey, and focus groups, that people are generally in support of alternative consent methods. Our PPI representatives have an important &nbsp;role in informing our research strategy, and their feedback improves our research process.\u201d<\/p>\n\n\n\n<p>One PPI representative explains: \u201cMy involvement in the PPI group makes it so much clearer to me how important it is to get patients&nbsp;involved in trials. I consider the recent changes for trials involving medicinal products a step forward in the right direction. The most important thing is for patients to be given the best available treatment at the appropriate time.\u201d As part of global collaborative efforts, ICC-CTN partners with like-minded research centres on a national and European level to advance trauma care.<\/p>\n\n\n<!DOCTYPE html PUBLIC \"-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\" \"http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\">\n<html><body><div style=\"text-align:center\" class=\"wp-block-atomic-blocks-ab-button ab-block-button\"><a href=\"https:\/\/iccctn.org\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"ab-button ab-button-shape-rounded ab-button-size-medium fb-pixel\" style=\"color:#ffffff;background-color:#394e23\">Click here to learn more<\/a><\/div>\n<\/body><\/html>\n\n\n\n<p><a id=\"_msocom_1\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Major trauma is a leading cause of critical illness, often requiring intensive care, organ support and mechanical breathing support, with young adults disproportionately affected. There is a growing need for effective pharmacological and non-pharmacological therapies which can reduce injury impact and improve recovery and patient outcomes following major trauma. Prof Alistair Nichol, Director of the &hellip; <a href=\"https:\/\/www.healthnews.ie\/clinical-trials\/new-emergency-trial-status-accelerates-major-trauma-research\/\">Continued<\/a><\/p>\n","protected":false},"author":91,"featured_media":12349,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5829],"tags":[5960],"class_list":["post-12345","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trials","tag-clinical-trials-2025"],"acf":[],"featured_image_src":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124943\/vicky-1742474982-AdobeStock_522959236-600x400.jpg","featured_image_src_square":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2025\/03\/20124943\/vicky-1742474982-AdobeStock_522959236-600x600.jpg","author_info":{"display_name":"henryphillips","author_link":"https:\/\/www.healthnews.ie\/author\/henryphillips\/"},"vicky_category_order":[{"category_id":5829,"order":"5"}],"vicky_index_order":"","_links":{"self":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/12345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/users\/91"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/comments?post=12345"}],"version-history":[{"count":4,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/12345\/revisions"}],"predecessor-version":[{"id":12435,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/12345\/revisions\/12435"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media\/12349"}],"wp:attachment":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media?parent=12345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/categories?post=12345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/tags?post=12345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}