{"id":12111,"date":"2024-12-12T10:43:18","date_gmt":"2024-12-12T10:43:18","guid":{"rendered":"https:\/\/www.healthnews.ie\/?p=12111"},"modified":"2024-12-13T08:45:41","modified_gmt":"2024-12-13T08:45:41","slug":"ppi-adaptive-trials-and-precision-therapeutics-changing-the-face-of-lung-failure-management","status":"publish","type":"post","link":"https:\/\/www.healthnews.ie\/respiratory\/ppi-adaptive-trials-and-precision-therapeutics-changing-the-face-of-lung-failure-management\/","title":{"rendered":"PPI, adaptive trials and precision therapeutics changing the face of lung failure management"},"content":{"rendered":"\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"518\" height=\"581\" class=\"ab-profile-avatar wp-image-12112\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/12\/12103514\/pp-Nichol-Alistair.jpg\" alt=\"\"\/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Prof Alistair Nichol<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Director, Irish Critical Care-Clinical Trials Network, University College Dublin<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"400\" class=\"ab-profile-avatar wp-image-12113\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/12\/12103654\/Leanne.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/12\/12103654\/Leanne.jpg 400w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/12\/12103654\/Leanne-125x125.jpg 125w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Dr Leanne Hays<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Respiratory and PPI Programme Manager, Irish Critical Care-Clinical Trials Network<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<p><em>Research networks advance innovation for ICU lung failure patients requiring mechanical ventilation by enhancing biological insights, conducting adaptive trials and involving patients and the public.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Often, ICU patients need breathing support, known as mechanical ventilation. Research on treatments for acute respiratory distress syndrome (ARDS) is often complicated due to its diverse causes, broad definition and varying patient responses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-few-advances-in-icu-care-for-lung-failure\"><strong>Few advances in ICU care for lung failure<\/strong><\/h2>\n\n\n\n<p>Professor Alistair Nichol, Director of Irish Critical Care-Clinical Trials Network (ICC-CTN), explains: \u201cThere have been few, if any, new therapies brought to the ICU to improve outcomes for patients needing respiratory support, particularly those with ARDS,\u201d he says. \u201cWe are looking into optimal ways to manage mechanical ventilation and identify drug therapies for ARDS patients.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-adaptive-trial-design-for-precision-medicine\"><strong>Adaptive trial design for precision medicine<\/strong><strong><\/strong><\/h2>\n\n\n\n<p>The ICC-CTN coordinates all-Ireland research and collaborates internationally to enhance ICU respiratory care. \u201cWe are seeking to overcome the limitations in methods of existing research by using adaptive platform trials, allowing us to ask multiple questions for the same disease at the same time with quicker answers within one established trial infrastructure,\u201d says Prof Nichol.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>We are seeking to overcome the limitations <br>in methods of existing research by <br>using adaptive platform trials.<\/p>\n<\/blockquote>\n\n\n\n<p>\u201cTrials require collaboration to answer questions globally and efficiently, which was highlighted at our recent meeting with organisations InFACT, ISARIC and attendees from platform trials and all continents,\u201d he adds. Different patient groups exhibit varying responses to the disease and its treatments, highlighting the potential for precision medicine, led by Professor Danny McAuley in Northern Ireland.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-patient-and-public-involvement-ppi\"><strong>Patient and public involvement (PPI)<\/strong><strong><\/strong><\/h2>\n\n\n\n<p>Dr Leanne Hays, Respiratory and PPI Programme Manager, highlights how active partnerships between researchers, patients and the public, are essential for meaningful progress. \u201cWe have established a programme of PPI, which is an extremely important part of how we inform our research,\u201d she says.<\/p>\n\n\n\n<p>Julianne Ahern, a member, shares her and husband Paul Deane\u2019s experience with the PPI. \u201cOver six years ago, I found myself in ICU by my husband\u2019s bed; he was in a coma with an uncertain outcome,\u201d she explains. \u201cPPI gives patients and families a voice and an opportunity to ask questions, voice concerns and, importantly, shed light and provide valuable input into trials. It\u2019s always patient-first with the PPI team: Kathy, Leanne and Alistair.\u201d<\/p>\n\n\n\n<div style=\"color:#32373c;background-color:#eb696c\" class=\"wp-block-atomic-blocks-ab-notice ab-font-size-18 ab-block-notice\" data-id=\"5e5432\"><div class=\"ab-notice-text\" style=\"border-color:#eb696c\"><p>To help drive clinical research in the ICU, see iccctn.org or email <a href=\"mailto:criticalcareppi@ucd.ie\" target=\"_blank\" rel=\"noreferrer noopener\">criticalcareppi@ucd.ie<\/a><\/p><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research networks advance innovation for ICU lung failure patients requiring mechanical ventilation by enhancing biological insights, conducting adaptive trials and involving patients and the public. Often, ICU patients need breathing support, known as mechanical ventilation. Research on treatments for acute respiratory distress syndrome (ARDS) is often complicated due to its diverse causes, broad definition and &hellip; <a href=\"https:\/\/www.healthnews.ie\/respiratory\/ppi-adaptive-trials-and-precision-therapeutics-changing-the-face-of-lung-failure-management\/\">Continued<\/a><\/p>\n","protected":false},"author":91,"featured_media":12114,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[130],"tags":[5957],"class_list":["post-12111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-respiratory","tag-respiratory-health-2024"],"acf":[],"featured_image_src":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/12\/12104213\/AdobeStock_563948316-600x400.jpg","featured_image_src_square":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/12\/12104213\/AdobeStock_563948316-600x600.jpg","author_info":{"display_name":"henryphillips","author_link":"https:\/\/www.healthnews.ie\/author\/henryphillips\/"},"vicky_index_order":"","_links":{"self":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/12111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/users\/91"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/comments?post=12111"}],"version-history":[{"count":1,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/12111\/revisions"}],"predecessor-version":[{"id":12115,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/12111\/revisions\/12115"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media\/12114"}],"wp:attachment":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media?parent=12111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/categories?post=12111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/tags?post=12111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}