{"id":11061,"date":"2024-03-26T15:10:41","date_gmt":"2024-03-26T15:10:41","guid":{"rendered":"https:\/\/www.healthnews.ie\/?p=11061"},"modified":"2024-03-28T21:12:43","modified_gmt":"2024-03-28T21:12:43","slug":"why-patient-centred-trials-lead-the-way-in-developing-treatment","status":"publish","type":"post","link":"https:\/\/www.healthnews.ie\/clinical-trials\/why-patient-centred-trials-lead-the-way-in-developing-treatment\/","title":{"rendered":"Why patient-centred trials lead the way in developing treatment"},"content":{"rendered":"\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"199\" class=\"ab-profile-avatar wp-image-11068\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/Professor-Fai-Ng-630x453-c.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/Professor-Fai-Ng-630x453-c.jpg 200w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/Professor-Fai-Ng-630x453-c-125x125.jpg 125w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Professor Fai Ng<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Director, CRF-UCC<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" class=\"ab-profile-avatar wp-image-11070\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/barry-plant.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/barry-plant.jpg 200w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/barry-plant-125x125.jpg 125w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Professor Barry Plant<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Consultant Respiratory Physician and Clinical Lead, Respiratory Medicine, CUH<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" class=\"ab-profile-avatar wp-image-11069\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/Sinead-Harney-Heashot.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/Sinead-Harney-Heashot.jpg 200w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205901\/Sinead-Harney-Heashot-125x125.jpg 125w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Professor Sinead Harney<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Consultant Rheumatologist, CUH<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<div style=\"background-color:#f2f2f2;color:#32373c\" class=\"wp-block-atomic-blocks-ab-profile-box round ab-has-avatar ab-font-size-14 ab-block-profile ab-profile-columns\"><div class=\"ab-profile-column ab-profile-avatar-wrap\"><div class=\"ab-profile-image-wrap\"><figure class=\"ab-profile-image-square\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" class=\"ab-profile-avatar wp-image-11066\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205902\/Frances-Shiely.jpg\" alt=\"\" srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205902\/Frances-Shiely.jpg 200w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205902\/Frances-Shiely-125x125.jpg 125w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure><\/div><\/div><div class=\"ab-profile-column ab-profile-content-wrap\"><h2 class=\"ab-profile-name\" style=\"color:#32373c\">Dr Frances Shiely<\/h2><p class=\"ab-profile-title\" style=\"color:#32373c\">Director of Education, CRF-UCC<\/p><div class=\"ab-profile-text\"><\/div><ul class=\"ab-social-links\"><\/ul><\/div><\/div>\n\n\n\n<p><em>Leveraging academic and clinical expertise centred on patient involvement can draw forth better clinical outcomes and more effective, innovative treatments.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>As the incoming director of the <a href=\"https:\/\/crf.ucc.ie\/\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical Research Facility at University College Cork (CRF-UCC)<\/a>, Professor Fai Ng believes there is a huge opportunity to develop the centre\u2019s research infrastructure, with people from all sectors at the core.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-benefits-of-patient-centred-trials\"><strong>Benefits of patient-centred trials<\/strong><\/h2>\n\n\n\n<p>As Professor of Rheumatology and former Director of the NIHR Newcastle CRF, Ng underlines the importance of staff, Principal Investigators (PIs), industry partners and patients working together. He believes that CRF-UCC has the potential to become country-leading in Ireland, and internationally, as researchers <a href=\"https:\/\/crf.ucc.ie\/\" target=\"_blank\" rel=\"noreferrer noopener\">develop new therapies<\/a>.<\/p>\n\n\n\n<p>The facility is co-funded by the Health Research Board and the College of Medicine and Health and can thus leverage academic and scientific excellence alongside clinical expertise across all medical specialties.<\/p>\n\n\n\n<p>\u201cClinical trials are important if we want to develop new and better medicines, but there are economic benefits as well,\u201d adds Ng, who takes up his new post on April 15.<\/p>\n\n\n<div id=\"healt-616134150\"><div class=\"healt-adlabel\">Advertisements<\/div><div id=\"healt-98770201\" style=\"margin-top: 30px;margin-bottom: 30px;margin-left: auto;margin-right: auto;text-align: center;\"><a data-no-instant=\"1\" href=\"https:\/\/crf.ucc.ie\/\" rel=\"noopener\" class=\"a2t-link\" target=\"_blank\" aria-label=\"UCC CRF2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2.jpg\" alt=\"\"  srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2.jpg 1563w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2-768x256.jpg 768w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2-1536x512.jpg 1536w\" sizes=\"auto, (max-width: 1563px) 100vw, 1563px\" width=\"750\" height=\"250\"  style=\"display: inline-block;\" \/><\/a><\/div><\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials-for-revolutionary-drugs\"><strong>Clinical trials for revolutionary drugs<\/strong><\/h2>\n\n\n\n<p>The facility has an established track record in developing treatments in all therapeutic areas from laboratory through clinical trials. For instance, from its initial work with the cystic fibrosis (CF) drug ivacaftor in 2011, it has continued to engage with clinical trials, including with ETI (elexacaftor-tezacaftor-ivacaftor) for CF, explains Professor Barry Plant, Consultant Respiratory Physician, Clinical Director for Medicine and Director of the Adult Cystic Fibrosis Centre at Cork University Hospital (CUH).<\/p>\n\n\n\n<p>\u201cThese new CF drugs are transformative and <a href=\"https:\/\/crf.ucc.ie\/\" target=\"_blank\" rel=\"noreferrer noopener\">revolutionising patient care<\/a>,\u201d he adds. Several CF patients being treated at CUH are involved in trials with new drugs and studies. Many participated in the CFMATTERS trial assessing how best to use intravenous antibiotics for infections in CF patients.<\/p>\n\n\n\n<p>Professor Plant explains telehealth and telemedicine approaches have also been supported to expand options for care delivery. His group is working with European bodies on these initiatives and looking at new ways of microbiology sampling to minimise cross-contamination and infection risk for patients, using next-generation bronchoscopy.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>These new CF drugs are transformative and revolutionising patient care.<\/p>\n<cite>Professor Barry Plant<\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-patient-focused-research\"><strong>Patient-focused research<\/strong><\/h2>\n\n\n\n<p>The CRF-UCC endeavours to deliver an infrastructure that enables busy academics and clinicians to conduct high-quality clinical research by providing access to expert staff including research nurses and statisticians, plus support around governance and ethics, and a patient-centred research environment<\/p>\n\n\n\n<p>Professor Sinead Harney, Consultant Rheumatologist at CUH and Honorary Clinical Professor at UCC, highlighted how CRF-UCC has enabled her to remain active in clinical trials and address ongoing \u2018unmet needs\u2019 for rheumatology patients.<\/p>\n\n\n\n<p>She is PI in Cork for the IDEA-FAST study that covers 14 other European countries investigating fatigue across inflammatory and neurodegenerative conditions. Other research areas include psoriatic arthritis and lupus.<\/p>\n\n\n<div id=\"healt-2603210796\"><div class=\"healt-adlabel\">Advertisements<\/div><div id=\"healt-2932201124\" style=\"margin-top: 30px;margin-bottom: 30px;margin-left: auto;margin-right: auto;text-align: center;\"><a data-no-instant=\"1\" href=\"https:\/\/crf.ucc.ie\/\" rel=\"noopener\" class=\"a2t-link\" target=\"_blank\" aria-label=\"UCC CRF2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2.jpg\" alt=\"\"  srcset=\"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2.jpg 1563w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2-768x256.jpg 768w, https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205857\/UCC-CRF2-1536x512.jpg 1536w\" sizes=\"auto, (max-width: 1563px) 100vw, 1563px\" width=\"750\" height=\"250\"  style=\"display: inline-block;\" \/><\/a><\/div><\/div>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-relevant-outcomes-for-patients\"><strong>Relevant outcomes for patients<\/strong><\/h2>\n\n\n\n<p>Dr Frances Shiely, Director of Education at the CRF, says patients are playing increasing roles in clinical trials. \u201cTwenty years ago, we used to do trials on patients,\u201d she says. \u201cNow, we do trials with patients.\u201d<\/p>\n\n\n\n<p>Patient and Public Involvement (PPI) sees patients working with researchers on trial design, recruitment, communication and dissemination of study findings ranging from new drugs to community-based interventions. There is also a move towards more decentralised clinical trials.<\/p>\n\n\n\n<p>PPI leads to better-quality, more efficient trials with better recruitment and design, delivering more relevant outcomes for patients. \u201cYou can only do that when you work with the patients,\u201d adds Dr Shiely.<\/p>\n\n\n\n<p>Clinical trials previously involved patients as passive subjects. Today, trials engage with patients as active collaborators. This shift empowers patients, fostering a deeper partnership between researchers and those with lived experiences.<\/p>\n\n\n\n<p>The CRF also offers a postgraduate certificate, postgraduate diploma and master\u2019s degrees in clinical trials (online) and conducts funded research projects to create inclusive clinical trials, plus training and education on increasing involvement in underserved groups.<\/p>\n\n\n<!DOCTYPE html PUBLIC \"-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\" \"http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\">\n<html><body><div style=\"text-align:center\" class=\"wp-block-atomic-blocks-ab-button ab-block-button\"><a href=\"https:\/\/www.linkedin.com\/company\/hrb-clinical-research-facility-cork\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"ab-button ab-button-shape-rounded ab-button-size-medium fb-pixel\" style=\"color:#ffffff;background-color:#0b65c2\">Follow us on LinkedIn<br>Click here<\/a><\/div>\n<\/body><\/html>\n","protected":false},"excerpt":{"rendered":"<p>Leveraging academic and clinical expertise centred on patient involvement can draw forth better clinical outcomes and more effective, innovative treatments. As the incoming director of the Clinical Research Facility at University College Cork (CRF-UCC), Professor Fai Ng believes there is a huge opportunity to develop the centre\u2019s research infrastructure, with people from all sectors at &hellip; <a href=\"https:\/\/www.healthnews.ie\/clinical-trials\/why-patient-centred-trials-lead-the-way-in-developing-treatment\/\">Continued<\/a><\/p>\n","protected":false},"author":23,"featured_media":11072,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5829],"tags":[5898],"class_list":["post-11061","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trials","tag-clinical-trials-q1-2024"],"acf":[],"featured_image_src":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205900\/GettyImages-1333889585-Converted-600x400.png","featured_image_src_square":"https:\/\/s3.eu-north-1.amazonaws.com\/cdn-site.mediaplanet.com\/app\/uploads\/sites\/94\/2024\/03\/07205900\/GettyImages-1333889585-Converted-600x600.png","author_info":{"display_name":"Your Future Career","author_link":"https:\/\/www.healthnews.ie\/author\/harveyodonnell\/"},"vicky_category_order":[{"category_id":5829,"order":"9"}],"vicky_index_order":"","_links":{"self":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/11061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/comments?post=11061"}],"version-history":[{"count":3,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/11061\/revisions"}],"predecessor-version":[{"id":11199,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/posts\/11061\/revisions\/11199"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media\/11072"}],"wp:attachment":[{"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/media?parent=11061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/categories?post=11061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthnews.ie\/wp-json\/wp\/v2\/tags?post=11061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}